In the recent past, several papers have pointed to the possibility that tumour removal generates a permissive environment in which tumour growth is potentiated. This phenomenon has been coined “perioperative tumour growth” and whilst it represents a departure in terms of our attitude to the surgical process, this concept was first hinted at by Paget1Sir James Paget (1814–1899) was a surgeon and physiologist who is widely held (along with Rudolph Virchow) to be the father of the science of pathology. Paget (...) described Paget's disease of the nipple as well as Paget's disease of bone. himself. Despite this, the time interval immediately before and after cancer surgery (i.e. the perioperative period) remains an underutilised interval during which chemotherapeutic regimens are rarely implemented. Herein, we present a summarised review of the literature that supports the concept that tumour removal may potentiate the growth of residual neoplastic disease. We also outline current knowledge regarding underlying mechanisms and in this manner highlight potential therapeutic entry points. Finally, we emphasise the urgent need for trials of agents that could protect patients against the harmful host–tumour interactions that may occur during the perioperative period. BioEssays 28: 433–437, 2006. © 2006 Wiley Periodicals, Inc. (shrink)

Nucleosome positioning is proposed to have an essential role in facilitating the regulated transcription of eukaryotic genes. Some transcription factors can bind to DNA when it is appropriately wrapped around the histone core, others cannot bind due to the severe deformation of DNA structure. The staged assembly of nucleosomes and positioning of histone‐DNA contacts away from promoter elements can facilitate the access of transcription factors to DNA. Positioned nucleosomes can also facilitate transcription through providing the appropriate scaffolding to bring regulatory (...) factors bound at dispersed sites into juxtaposition. (shrink)

Nucleosome positioning is proposed to have an essential role in facilitating the regulated transcription of eukaryotic genes. Some transcription factors can bind to DNA when it is appropriately wrapped around the histone core, others cannot bind due to the severe deformation of DNA structure. The staged assembly of nucleosomes and positioning of histone‐DNA contacts away from promoter elements can facilitate the access of transcription factors to DNA. Positioned nucleosomes can also facilitate transcription through providing the appropriate scaffolding to bring regulatory (...) factors bound at dispersed sites into juxtaposition. (shrink)

Live donor kidney transplantation is the best treatment option for most patients with late-stage chronic kidney disease; however, the rate of living kidney donation has declined in the United States. A consensus conference was held June 5-6, 2014 to identify best practices and knowledge gaps pertaining to live donor kidney transplantation and living kidney donation. Transplant professionals, patients, and other key stakeholders discussed processes for educating transplant candidates and potential living donors about living kidney donation; efficiencies in the living donor (...) evaluation process; disparities in living donation; and financial and systemic barriers to living donation. We summarize the consensus recommendations for best practices in these educational and clinical domains, future research priorities, and possible public policy initiatives to remove barriers to living kidney donation. (shrink)

The recent surge of discoveries concerning the structural organization of nucleosomes, together with genetic evidence of highly specialized roles for the histones in gene regulation, have brought a renewed need for a detailed understanding of nucleosomal anatomy. Here we review recent structural advances leading to a new level of understanding of the nucleosome and chromatin fibre structure. We discuss the problems and challenges for existing models of chromatin structure and, in particular, consider how linker histones may bind within the nucleosome, (...) together with the implications of their association for the structure of the chromatin fibre. (shrink)

© 2016 Regents of the University of California.The Review summarizes much of particle physics and cosmology. Using data from previous editions, plus 3,062 new measurements from 721 papers, we list, evaluate, and average measured properties of gauge bosons and the recently discovered Higgs boson, leptons, quarks, mesons, and baryons. We summarize searches for hypothetical particles such as supersymmetric particles, heavy bosons, axions, dark photons, etc. All the particle properties and search limits are listed in Summary Tables. We also give numerous (...) tables, figures, formulae, and reviews of topics such as Higgs Boson Physics, Supersymmetry, Grand Unified Theories, Neutrino Mixing, Dark Energy, Dark Matter, Cosmology, Particle Detectors, Colliders, Probability and Statistics. Among the 117 reviews are many that are new or heavily revised, including those on Pentaquarks and Inflation. The complete Review is published online in a journal and on the website of the Particle Data Group. The printed PDG Book contains the Summary Tables and all review articles but no longer includes the detailed tables from the Particle Listings. A Booklet with the Summary Tables and abbreviated versions of some of the review articles is also available. (shrink)

Michael A. PetersBeijing Normal University, Beijing, PR China;There is an ecology of bad ideas, just as there is an ecology of weeds– Gregory Bateson (1972, p. 492)While there are classical anteced...

L'on montre: 1) que l'affirmation tschirnhausienne selon laquelle l'art de découvrir transforme notre nature en une nature quasi surhumaine qui semble assez participer de celle de Dieu, et en laquelle C. Thomasius avait subodoré un fort relent spinoziste, est explicable, et est effectivement expliquée par Tschirnhaus dans sa Medicina mentis, d'une façon qui ne saurait effaroucher un théologien orthodoxe; 2) que, malgré la modernité de certaines vues de Tschirnhaus relatives au rôle de l'expérience, cet auteur n'a pas perçu la véritable (...) fonction de la „confirmation" expérimentale, contrairement à ce qu'on admet fréquemment de nos jours; 3) pourquoi il convient de penser que c'est dans Spinoza que Tschirnhaus a puisé sa conception des définitions génétiques; 4) que, contrairement à l'opinion courante, ie manuscrit de la Mediana mentis a vraisemblablement été envoyé en Hollande en latin . Suivent des indications bibliographiques et un erratum. (shrink)

The most recent commentator on this line, D. R. Shackleton Bailey, states that ‘spiritus is breath rather than odour’ and he has the support of some commentators, Marcilius, for example, who amends notus to motus, and Hertzberg, who takes it as sweet breath, citing Mart. 3. 65. 1. So also most translators : an exception is D. Paganelli who translates ‘aucun souffle, aucune odeur d'adultère’. However, the parallels cited by Shackleton Bailey are irrelevant to this situation: Afranius 243, Ach. Tat. (...) 2. 37. 9, and Claud. Carm. Min. 29. 33 all refer to the period just before, during, or immediately after the sexual act. It is most unlikely that this is the case in Propertius' poem. Propertius has come to see if Cynthia has spent the night alone; it is not a question of catching her inflagrante delicto, but of finding some rival there or the evidence of his stay not yet removed. Cynthia is indignant at her lover's suspicions and lest he should think that his rival had left earlier, she coarsely specifies the evidence that Propertius might expect to find, including spiritus admisso notus adulterio. (shrink)

Discusssion of passages 243 et. seq. of Wittgenstein's Philosophical lnvestigations tends to concentrate on the argument supporting the thesis that a logically private language is impossible. When the discussion becomes broader, the presumption is generally that this thesis is one premifs of an argument against solipsism. I believe that the passages will support a valid argument that might, at first glance, give comfort to someone in the egocentric predicament, but that this comfort would quickly grow cold on closer examination. I (...) do not mean to suggest that Wittgenstein offers no escape from the predicament, only that the escape will not be a consequence of the pluralism necessary to the existence of language, but rather a byproduct of his discussion of the logic of mental discourse. In this paper, I state an alternative to the contra-solipsist reading of the passages, taking Wittgenstein there to be reflecting a three part dispute, the other participants of which are a skeptic and a philosopher I'll call ‘the Realist'. (shrink)

Modernism is both a contested aesthetic category and a powerful political statement. Modernist music was condemned as degenerate by the Nazis and forcibly replaced by socialist realism under the Soviets. Sympathetic philosophers and critics have interpreted it as a vital intellectual defence against totalitarianism, yet some American critics consider it elitist, undemocratic, and even unnatural. Drawing extensively on the philosophy of Heidegger and Badiou, Quilting Points proposes a new dialectical theory of faithful, reactive, and obscure subjective responses to musical modernism, (...) which embraces all the music of Western modernity. (shrink)

Naturalism provides a rigorous analysis and critique of the major varieties of contemporary philosophical naturalism. The authors advocate the thesis that contemporary naturalism should be abandoned, in light of the serious objections raised against it. Contributors draw on a wide range of topics including: epistemology, the philosophy of science, the philosophy of mind and agency, and natural theology.